Table 4.
Examples of the Measurement of IgG and IgGSc for Screening Individuals Presenting With Different RIs
| Type of Infection | Normal IgG (%) | Low IgGSc Concentration | Comments Regarding IgGScD | Reference |
|---|---|---|---|---|
| Chronic and recurrent ear, nose, and throat | 101/103 (98) | 4/101 (4) | Response to Pneumococcal vaccination normal in 1/4 IgGScD (25%) 1/4 IgGScD developed bronchiectasis |
Aghamohammadi et al78 |
| Upper respiratory tract infection with otitis media/lower respiratory tract infection with pneumonia | 22/55 (47)a | 22/22 (100) | IgGScD as follows: 3 IgG1, 8 IgG2, 11 IgG3. 3/7 patients with low IgA had IgGScD. | Bossuyt et al 71 |
| Recurrent bronchitis | 23/25 (92) | 17/25 (68) | IgGScD as follows: 2 IgG2, 4 IgG3 and 7 IgG4. 4 combined IgGScD. |
De Baets et al55 |
| Chronic and recurrent rhinosinusitis | 70/74 (95) | 33/70 (47) | 5 low IgG1, 3 low IgG2, 19 low IgG3, 6 low IgG4—7 with >1 low IgGSc | Scadding et al33 |
| Therapy refractory recurrent rhinosinusitis | 240/245 (98) | 17/240 (7) | IgGScD as follows: 5 IgG1, 10 IgG2, 1 IgG3, and 1 IgG4. 3/17 had an inadequate pneumovax response | May et al112 |
aIn 2 patients with low IgG2, they had low total IgG.