Table 2.

Levels of total B₁p(PHB)B₂ phosphate adducts, total B₁p(POB)B₂ phosphate adducts, total POB base adducts, and total PHB base adducts in lung tissue of rats treated with 5 ppm of (R)-NNAL, (S)-NNAL and NNK in drinking water for 10, 30, 50 or 70 weeks

Treatment	Adduct	Level (fmol/mg DNA)
		10 weeks	30 weeks	50 weeks	70 weeks
(R)-NNAL	B1p(PHB)B2	4530 ± 368	6670 ± 211	6280 ± 336	6920 ± 436
	B1p(POB)B2	136 ± 32	135 ± 30	175 ± 17	46d
	PHB basea	4880 ± 721	7440 ± 507	6670 ± 885	6170 ± 1770
	POB basea	323 ± 36	490 ± 81	720 ± 46	545 ± 112
	Total	9870 ± 811	14700 ± 556	13800 ± 948	13700 ± 1820
(S)-NNAL	B1p(PHB)B2	3670 ± 67	4180 ± 119	3480 ± 79	3820 ± 582
	B1p(POB)B2	4650 ± 356	2910 ± 109	1310 ± 77	1180 ± 204
	PHB basea	847 ± 34	1210 ± 30	1250 ± 48	1270 ± 311
	POB basea	3180 ± 664	3950 ± 371	4530 ± 335	4470 ± 265
	Total	12400 ± 757	12200 ± 406	10600 ± 356	10700 ± 740
NNK	B1p(PHB)B2b	6390 ± 457	8160 ± 654	4000 ± 291	3950 ± 223
	B1p(POB)B2c	475 ± 95	417 ± 43	346 ± 41	218 ± 15
	PHB basea	1200 ± 49	1530 ± 104	1390 ± 74	869 ± 143
	POB basea	4600 ± 440	5570 ± 195	5110 ± 327	2300 ± 473
	Total	12600 ± 643	15700 ± 692	10800 ± 446	7340 ± 542

Values are presented as means ± SD (n = 3 or 5).

^aThe data of POB and PHB base adduct levels in rat lung are from Balbo, S., et al. (2014) Carcinogenesis, 35, 2798–2806.

^bThe data of total B₁p(PHB)B₂ phosphate adduct levels are from (10).

^cThe data of total B₁p(POB)B₂ phosphate adduct levels are from Ma, B., et al. (2015) Chem. Res. Toxicol., 28, 2151–2159.

^dSingle measurement.