TABLE 2.
Gene list and descriptions from DAVID bioinformatics database (https://david.ncifcrf.gov)
| No. | Name | Full Name | Description | Reference |
|---|---|---|---|---|
| 1 | BOC | BOC cell adhesion associated, oncogene regulated | Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells | Tenzen et al. (2006) |
| 2 | CLEC4GP1 | C-type lectin domain family 4 member G pseudogene 1 | Function unknown | |
| 3 | ELOVL6 | ELOVL fatty acid elongase 6 | Fatty acid elongase specific to C12-C16 saturated and monounsaturated fatty acids | Feng et al. (2016) |
| 4 | EREG | epiregulin | May be a mediator of localized cell proliferation | Riese and Cullum (2014) |
| 5 | ESR2 | estrogen receptor 2 | Nuclear hormone receptor that binds estrogens with an affinity similar to that of ESR1 and activates expression of reporter genes containing estrogen response elements in an estrogen-dependent manner | Batistatou et al. (2004), Sareddy et al. (2016) |
| 6 | FDCSP | follicular dendritic cell secreted protein | Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells | Wang et al. (2010), Hou et al. (2014) |
| 7 | FURIN | furin, paired basic amino acid cleaving enzyme | Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys and regulates TGF-β bioavailability | Phillips-Mason et al. (2014) |
| 8 | FUT8-AS1 | fucosyltransferase 8 antisense RNA 1 | Fucosylation of proteins, including EGFR | Liu et al. (2011) |
| 9 | GZMB | granzyme B | This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. It has been associated with both tumor progression and regression, in a case-dependent manner. | Medema et al. (2001), Rousalova and Krepela (2010) |
| 10 | IRX3 | iroquois homeobox 3 | Belongs to the TALE/IRO homeobox family and may have a direct functional relationship to both obesity and type 2 diabetes. IRX3 is a proneural gene important for neuronal differentiation. | Yang et al. (2010), Seol et al. (2011) |
| 11 | LITAF | lipopolysaccharide induced TNF factor | Probable role in regulating transcription of specific genes. May regulate through NF-κB1 the expression of the CCL2/MCP-1 chemokine. May play a role in TNF-alpha gene expression. | Zou et al. (2015) |
| 12 | NDEL1 | nudE neurodevelopment protein 1 like 1 | Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. | Hong et al. (2016) |
| 13 | NKX3-1 | NK3 homeobox 1 | Transcription factor, which binds preferentially the consensus sequence 5′-TAAGT[AG]-3′ and can behave as a transcriptional repressor. Could play an important role in regulating proliferation of glandular epithelium and in the formation of ducts in prostate. | Bhatia-Gaur et al. (1999) |
| 14 | PODNL1 | podocan like 1 | Belongs to the small leucine-rich proteoglycan (SLRP) family | Heyn et al. (2013), Yan et al. (2013), Teng and Zheng (2017) |
| 15 | PTPRN | protein tyrosine phosphatase, receptor type N | Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. | Xie et al. (1996), Bauerschlag et al. (2011) |
| 16 | QSOX1 | quiescin sulfhydryl oxidase 1 | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. | Katchman et al. (2011) |
| 17 | SEMA4F | semaphorin 4F | Estrogen-regulated semaphorin ligand with growth cone collapse activity against retinal ganglion-cell axons | Parrinello et al. (2008) |
| 18 | TH | tyrosine hydroxylase | Plays an important role in the physiology of adrenergic neurons | Tekin et al. (2014) |
| 19 | VEGFC | vascular endothelial growth factor C | Growth factor active in angiogenesis and endothelial cell growth, stimulating proliferation and migration. Has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and in the maintenance of differentiated lymphatic endothelium in adults. | Denicolaï et al. (2016), Dufies et al. (2017) |
| 20 | C20orf166AS1 | chromosome 20 open reading frame 166 antisense RNA 1 | Long noncoding RNA | Hu et al. (2014) |
TNF, tumor necrosis factor.