Table 1.

Total MRI small vessel disease score: MRI markers, definitions and points.

MRI marker	Definition	Score
Lobar CMBs	2–4 CMBs	1 point
	≥ 5 CMBs	2 points
cSS	Focal cSS (≤3 sulci)	1 point
	Disseminated cSS (≥4 sulci)	2 points
CSO-EPVS	Moderate-to severe, i.e. ≥20 CSO-EPVS	1 point
WMH	Confluent deep WMH (Fazekas score 2 or 3) and/or irregular periventricular WMH extending into the deep white matter (Fazekas score 3)	1 point
from Charidimou et al.3

CMBs=cerebral microbleeds, cSS=cortical superficial siderosis, CSO-EPVS=centrum semiovale - enlarged perivascular spaces, WMH=white matter hyperintensities