Fig 4. Radical cure primaquine policies in Asia, Oceania, and Middle East countries.

All countries have policies to use primaquine for radical cure of vivax malaria, mainly as 0.25 mg/kg/day for 14 days, with some countries using the weekly regimen (0.75 mg/kg once weekly for 8 weeks). Colours indicate requirement for G6PD deficiency testing before primaquine administration: blue—G6PD deficiency testing required, red—testing not required, with light red or blue for unobserved therapy and dark red or blue for directly observed therapy (DOT). Implementation of these policies, regimens used, and requirement for G6PD deficiency testing vary between countries. Table 5 provides details on countries’ policies, implementation, and/or upcoming modifications.