Table 3. Malaria, G6PD deficiency, and indications for primaquine in different malaria-endemic regions.

Region	Parasite species	Common G6PDd variants	Recommended primaquine regimens
Africa	Mostly Pf	Mostly A-	Gametocytocidal single dose for Pf in low-transmission areas
Asia, Oceania, Middle East	Both Pf and Pv (close to 50:50 in many countries) P. knowlesi accounted for 38% of malaria reported cases in Malaysia in 2014 [56]	Several, including Mahidol, Viangchan, Kaiping, Canton, Orissa, and Mediterranean. Generally more severe than A-.	Gametocytocidal single dose for Pf; radical cure for Pv
The Americas	Both Pf and Pv (overall around 75% Pv, 25% Pf)	Mostly A-	Gametocytocidal single dose for Pf; radical cure for Pv

Abbreviations: Pf, Plasmodium falciparum; Pv, P. vivax