Table 1. Characteristics of study paticipants according to clinical presentation.
| Characteristics | HC (n = 119) | CHB (n = 100) | LC (n = 69) | HCC (n = 118) |
|---|---|---|---|---|
| Age (years) | 23.76 [19–75] | 42.6 [19–85] | 58.6 [27–87] | 55.6 [23–92] |
| Gender (M/F) | 92/27 | 92/8 | 52/17 | 108/10 |
| AST | 31.7 [20–37] | 376.1 [26–6206] | 128.9 [24–1038] | 92.2 [20–563] |
| ALT | 31.6 [21–36] | 406.9 [9–3390] | 86.4 [6–1000] | 61.3 [11–391] |
| Total bilirubin (mg/dl) | 8.8 [4.8–15.3] | 55.1 [8.4–551] | 70.4 [6.2–514.5] | 19.0 [4.8–86.3] |
| Direct bilirubin (mg/dl) | 4.7 [1.7–9.3] | 25.8 [1.0–349] | 31.8 [1.6–258.6] | 7.1 [0.7–53.3] |
| Albumin | NA | 39.4 [25.0–48] | 31.3 [19–46] | 38.5 [22.4–48] |
| Total Protein | NA | 73.6 [51.0–90] | 71.4 [54–97] | 76.9 [59–92.6] |
| AFP | NA | 43.9 [0.87–917] | 26.6 [0.9–154.2] | 565.1 [0.8–16660] |
| AFP < 20 ng/ml | NA | 73 (73.0) | 46 (66.7) | 41 (34.7) |
| Prothrombin* (% of standard) | NA | 87.5 [17.0–152] | 60.0 [26.9–138] | 93 [49–123] |
| WBC* 109/L | NA | 6.9 [2.9–16.2] | 5.8 [1.7–15.2] | 7.4 [2.89–17.9] |
| RBC* 1012/L | NA | 4.8 [3.1–6.] | 3.8 [2.2–6] | 4.7 [3.1–7.2] |
| PLT* 109/L | NA | 186.6 [55–416] | 90.49 [29–279] | 191.8 [38–479] |
| HBV load* (copies/ml) | negative | 2.3x108 [<100–3.69x109] |
8.14x107 [<100–1.25x109] |
3.11x106 [<100–3.72x107] |
| Child-Pugh | ||||
| A | NA | NA | 29 (42.1) | 105 (89) |
| B | NA | NA | 25 (36.2) | 4 (3.4) |
| C | NA | NA | 15 (21.7) | 1 (0.8) |
| Unknow | NA | NA | 8 (6.8) | |
| Tumor number | ||||
| 1 | NA | NA | NA | 69 (58.5) |
| 2–3 | NA | NA | NA | 16 (13.6) |
| > 3 | NA | NA | NA | 32 (27.1) |
| Unknown | NA | NA | NA | 1 (0.8) |
| Tumor size (cm) | ||||
| < 2 | NA | NA | NA | 1 (0.8) |
| 2 - < 3 | NA | NA | NA | 7 (5.9) |
| 3 - < 5 | NA | NA | NA | 27 (22.9) |
| 5 - < 10 | NA | NA | NA | 47 (39.8) |
| > 10 | NA | NA | NA | 35 (29.8) |
| Unknown | NA | NA | NA | 1 (0.8) |
| Maximum tumor size (cm) | NA | NA | NA | 7.7 [1.1–16.2] |
| Vascular invasion | ||||
| Yes | NA | NA | NA | 30 (25.5) |
| No | NA | NA | NA | 87 (73.7) |
| Unknown | NA | NA | NA | 1 (0.8) |
| Metastasis | ||||
| Yes | NA | NA | NA | 21 (17.8) |
| No | NA | NA | NA | 95 (80.5) |
| Unknown | NA | NA | NA | 2 (1.7) |
| Tumor differentiation | ||||
| High | NA | NA | NA | 28 (23.7) |
| Intermediate | NA | NA | NA | 53 (44.9) |
| Low | NA | NA | NA | 11 (9.3) |
| Unknown | NA | NA | NA | 26 (22.1) |
| BCLC staging | ||||
| O | NA | NA | NA | 0 (0) |
| A | NA | NA | NA | 5 (4.2) |
| B | NA | NA | NA | 67 (56.8) |
| C | NA | NA | NA | 36 (30.5) |
| D | NA | NA | NA | 0 (0) |
| Unknown | NA | NA | NA | 10 (8.5) |
CHB, chronic hepatitis B; LC, liver cirrhosis; HCC, hepatocellular carcinoma; WBC, white blood cell; RBC, red blood cell; PLT, platelet; AST and ALT, aspartate and alanine amino transferase; IU, international units; AFP, alpha-fetoprotein; BCLC, Barcelona Clinic Liver Cancer stage; NA, not available. Values given are with medians and ranges;
*, P < 0.05 for comparison with all other groups.