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. 2018 Feb 23;22(5):2706–2716. doi: 10.1111/jcmm.13554

Figure 1.

Figure 1

The level of iNKT cells frequency is reduced and significantly related with bone disease in newly diagnosed multiple myeloma (NDMM) patients. A, The percentages of Vα24+Vβ11+ T (iNKT) and CD4+, CD8+ and CD4− CD8− iNKT cell in T cells were examined by flow cytometry. B, The percentage of iNKT cells was significantly lower in patients with NDMM and relapsed/refractory MM (RMM) than that in healthy controls (HCs). The percentage of iNKT cells in MM patients achieved remission rised again compared with untreated NDMM patients. C, About the percentages of CD4− CD8+ and CD4− CD8− (double‐negative, DN) iNKT cells of T cells, NDMM and RMM patients had significantly lower than HCs, while MM patients achieved remission had significantly higher than untreated NDMM patients. D, The percentage of iNKT cells was significantly lower in the patients with Stage C bone disease than those with Stage A/B bone disease and HCs. E, The percentage of iNKT cells was significantly correlated with the level of carboxy‐terminal cross‐linking telopeptide of type I collagen (CTX) respectively by Spearman's correlation coefficient. F, The percentages of iNKT cells were significantly correlated with the percentages of osteoclast precursors (OCPs) respectively by Spearman's correlation coefficient. G, The percentage of CD4− CD8+ iNKT cells was significantly lower in the patients with Stage C bone disease than those with Stage A/B bone disease and HCs. (Medians of each group were compared using Kruskal‐Wallis test followed by all pairwise multiple comparisons; *P < .05, **P < .01, ***P < .001)