Figure 6.

BAY 11‐7082 inhibits bile‐induced nuclear translocation of phospho‐NF‐κB and phospho‐STAT3 in normal human hypopharyngeal cells. Immunofluorescence staining of (A) phospho‐NF‐κB (p‐p65 S536) and (B), phospho‐STAT3 (Tyr705) reveals that application of BAY 11‐7082 particularly inhibits the p‐NF‐κB and p‐STAT3 nuclear translocation in acidic bile‐treated human hypopharyngeal primary cells (HHPC), demonstrating decreased p‐p65 and p‐STAT3 nuclear staining [green: p‐p65 (S536) or pSTAT3 (Tyr705); blue: DAPI for nuclear staining]