Figure 4.

Systemic administration of 2-DG (2-deoxyglucose) to rats post-myocardial infarction (MI) caused dose-dependent downregulation of IL (interleukin)-1β gene expression in infarct tissue and also normalized hyperpolarized [1-¹³C]lactate signal (n=4–5 evaluable datasets per group). 2-DG had no significant effect on expression of genes encoding the proreparative factors IL-10, VEGF-C (vascular endothelial growth factor C), and TGF-β (transforming growth factor-β; n=3–4 biological replicates per group; 1-way ANOVA with the Holm–Sidak correction for multiple comparisons) Cine MRI analysis demonstrated that 2-DG attenuated the rate of decline in left ventricle (LV) systolic function between day 3 and 3 months (n=9 biological replicates per group to give 7–9 evaluable data sets; unpaired unequal variance t test). *P≤0.05, **P≤0.01, ***P≤0.001.