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. 2018 Mar 30;9(24):16588–16598. doi: 10.18632/oncotarget.24742

Figure 2. The anti-OCLN mAb 67-2 prevents HCV infection in double-chamber culture system.

Figure 2

(A) Illustration of Huh7.5.1 cell culture system using double-chamber methods to verify HCV infection. (B) Huh7.5.1 cells grown in double-chamber system were exposed to HCVcc and either mock, mIgG (50 μg), anti-CD81 mAb (2.5 μg) or anti-OCLN-EC2 mAbs (50 μg), and total RNA from the cells was subjected to real-time RT-PCR analysis for the NS5A expression. The infection levels were expressed relative to the amount of the mock-treated cells, which was taken as 1. All values represent the mean ± SD (error bars; n = 5). Statistic values were determined compared with those in the mIgG-treated cells; *P < 0.01.