Figure 1. ALCAM expression presented a different correlation profile depending on its localization within the tumor and its decrease at the invasive front is a marker of myometrial invasion.

(A) Upper: Full-length ALCAM was significantly and positively correlated with the E-cadherin/β-catenin complex at the superficial tumor and is mainly localized at the cell membrane. Down: At the invasive front, full-length ALCAM is significantly inversely correlated with MMP-9 and ETV5, in the moderately-poorly differentiated EEC. (B) ALCAM-negativity, at the invasive front, is a marker of myometrial invasion (C) At the invasive front, ALCAM-negative tumors increased from a 21.8% in patients without myometrial invasion to a 45.1% in patients presenting myometrial infiltration (p-value= 0.014).