Figure 2. Effect of cis-khellactone on the cell proliferation and viability of MCF7, MDA-MB-231, and MCF10A breast cancer and normal cell lines.

Growth curve of MCF7 (A), MDAMB-231 (B), and MCF10A (C) cells are shown after treatment with indicated concentrations of cis-khellactone. MCF7, MDA-MB-231, and MCF10A cells were treated with DMSO alone (control) or with 1, 2.5, 5, 10 or 20 μg/ml of cis-khellactone for 24, 48, or 72 h. After indicated time periods, the cells were collected and viability was evaluated as described in Materials and Methods. The number represents the viable cells of each cell line.