Table 2. Summary of biological activities of the compounds (1)–(6) in human prostate cancer cells.
Actitiy* | Compound | |||||
---|---|---|---|---|---|---|
(1) | (2) | (3) | (4) | (5) | (6) | |
Cytotoxicity | ++ | +++ | + | +++ | + | ++ |
Anti-proliferative activity | + | ++ | + | ++ | + | + |
Pro-apoptotic activity | ++ | +++ | + | +++ | + | ++ |
Autophagy inhibition | ++ | ++ | +++ | +++ | + | + |
AR signaling inhibition | – | +++ | – | +++ | - | ++ |
*“+++” – high activity; “++” – moderate activity; “+” – low activity; “–” – no activity.