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. 2018 Mar 30;9(24):17117–17132. doi: 10.18632/oncotarget.24965

Figure 3. Pharmacokinetics of 89Zr-DFO-nimotuzumab in normal balb-C mice.

Figure 3

89Zr-DFO-nimotuzumab exhibits a biphasic kinetics with distribution and elimination half-lives of 1.3 (t1/2α) and 127.1 (t1/2β), respectively. The volume of distribution of the central compartment (V1) was 3.2±0.3 mL mL (107 mL/kg) and the volume of distribution at steady state (Vss) was 8.6±3.4 mL (287 mL/kg). The V1 and Vss volumes correspond to 7.5 L and 20.1 L respectively, in a 70 kg standard adult female. The systemic clearance (CLs) was 0.045±0.0020 mL/h (1.5 mL/h/kg). The CLs values in mice would correspond to 105 mL/h in a 70 kg adult female.