Figure 5.

(A–D) PET/CT imaging and image analyses in mice xenografts. (A) Maximum intensity projection (MIP) PET/CT images of a representative mouse bearing EGFR-positive DLD-1 and MDA-MB-468, and control MDA-MB-435 xenografts at different time points post ⁸⁹Zr-DFO-nimotuzumab injection. Xenografts are located in right thigh of the hind leg. (B) Except at 24 h post injection, significantly higher tumor uptake was seen in EGFR xenografts compared with control xenograft. (C) Tumor/muscle and (D) Tumor/liver ratios in same mice groups.