Table 2. Prognostic features and their potential targets of miRNAs.
| Author (Year) | Cut-off value |
Follow- up (month) |
miRNA | Sample size | Reference | OS | Potential targets | Expression associates with poor prognosis | |
|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P | ||||||||
| S. Azizmohammadi (2016) |
Median (NA) |
60 | miRNA-145 | 35 | L:H | a 2.62 (1.134–6.362) |
0.031 | _ | Low |
| Fan (2015) | Mean (NA) |
42 | miRNA-125a | 55 | H:L | b 0.691 (0.418–1.141) |
_ | STAT3 | Low |
| Wang (2015) | Median (2.5) | median 47 | miRNA-145 | 114 | H:L | a 0.63 (0.54–0.83) |
0.008 | _ | Low |
| Liu (2015) | Mean (3.880) | 80 | miRNA-196a | 105 | H:L | a 3.510 (1.961–6.874) |
0.025 | _ | high |
| Hou (2013) | Median (NA) |
median 45.6 (1.2–60) |
miRNA-196a | 92 | L:H | b 0.266 (0.028–2.542) |
_ | FOXO1 and p27Kip1 | high |
| Huang (2012) | Mean (3.871) | mean 23.6 | miRNA-125b | 44 | H:L | a 0.352 (0.102–1.014) |
0.057 | _ | low |
| Huang (2012) | Mean (8.941) |
mean 23.6 | miRNA-145 | 44 | H:L | c 0.58 (0.32–1.05) |
0.072 | _ | low |
NA, not available; L, low expression of miRNA; H, high expression of miRNA; a extracted from multivariate analyses; b estimated base on Kaplan-Meier survival curves; c extracted from univariate analyses.