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Schematic illustration of a) the synthesis of HMONs‐ss‐Cu2− xSe (HCu) nanosystems, b) the composition and biodegradable behavior of DOX‐HCu, c) enhanced delivery of DOX‐HCu nanosystems into brain tumor through FUS‐induced BBB opening and subsequent biodegradation of DOX‐HCu caused by the high GSH concentration in the TME.
