Table 2.
Treatment outcomes from 7 days of either placebo or zinc
| Outcomes | Placebo n/N (%) | Zinc n/N (%) | OR (95% CI)* | P-value |
|---|---|---|---|---|
|
Treatment failure: |
||||
| Day-5 |
41/293 (14.0) |
42/298(14.1) |
1.08(0.65,1.80) |
0.773 |
| Day-10 |
15/286 (5.2) |
17/290(5.9) |
1.18(0.54,2.60) |
0.682 |
| Median (IQR) time to resolution (hours) |
Placebo median (N)† |
Zinc median (N)† |
Ratio (95% CI)† |
P-value |
| Oxygen saturation <90% |
7.2 (42) |
5.9 (36) |
1.33 (0.82,2.14) |
0.251 |
| Lower chest wall indrawing |
24.4 (258) |
23.0 (257) |
0.84 (0.74,0.96) |
0.011 |
| Nasal flaring |
13.4 (245) |
13.2 (243) |
0.96 (0.83,1.11) |
0.574 |
| Grunting |
4.9 (109) |
5.3 (81) |
1.11 (0.85,1.44) |
0.448 |
| Head nodding |
4.0 (25) |
3.3 (31) |
0.71 (0.39,1.31) |
0.274 |
| Sternal retraction |
18.7 (21) |
11.0 (23) |
0.51 (0.31,0.82) |
0.006 |
| Central cyanosis |
1.4 (12) |
1.8 (12) |
0.60 (0.31,1.15) |
0.121 |
| Respiratory rate ≥50 per min |
21.0 (272) |
17.9 (270) |
0.89 (0.76,1.04) |
0.142 |
| Respiratory rate ≥40 per min |
54.1 (297) |
51.4 (302) |
1.13 (0.95,1.34) |
0.168 |
| All signs of severity‡ |
42.3 (36) |
30.9 (31) |
0.81 (0.58,1.15) |
0.242 |
| Discharge | 95.9 (292) | 94.7 (296) | 1.04 (0.94,1.15) | 0.468 |
*Adjusted for baseline age, sex, height for age, weight for age, and weight for height z scores and pneumonia severity.
†Number of participants with the symptom at baseline.
‡Oxygen saturation <90%, lower chest wall indrawing, nasal flaring.