Table 5.
Adjusted Mean (Standard Error) of Hippocampal Whole and Subfield Volumes for Heavy and Light User Groups
| Heavy (n=9) | Light (n=9) | |||||
|---|---|---|---|---|---|---|
| Baseline | Post-treatment | Baseline | Post-treatment | Time p | Time by group p | |
| Whole hippocampus | ||||||
| Left | 3822.57 (60.57) | 3872.15 (62.23) | 4058.73 (60.57) | 4052.10 (62.23) | 0.197 | 0.198 |
| Right | 4025.95 (71.47) | 4036.63 (68.91) | 4228.35 (71.47) | 4201.36 (68.91) | 0.157 | 0.507 |
| Subicular complex | ||||||
| Left | 857.42 (20.96) | 884.06 (22.77) | 912.94 (20.96) | 914.28 (22.77) | 0.683 | 0.104 |
| Right | 871.28 (22.48) | 865.40 (20.59) | 860.38 (22.48) | 858.71 (20.59) | 0.254 | 0.780 |
| Parasubiculum | ||||||
| Left | 61.74 (3.30) | 62.71 (3.74) | 66.98 (3.30) | 69.64 (3.74) | 0.591 | 0.471 |
| Right | 66.50 (2.69) | 65.56 (2.16) | 63.44 (2.69) | 63.03 (2.16) | 0.195 | 0.322 |
| Presubiculum | ||||||
| Left | 336.55 (9.00) | 350.70 (9.00) | 348.41 (9.00) | 344.83 (9.00) | 0.752 | 0.015* |
| Right | 336.50 (14.10) | 334.65 (14.92) | 332.93 (14.10) | 326.07 (14.92) | 0.341 | 0.436 |
| Subiculum | ||||||
| Left | 459.13 (15.99) | 470.64 (16.76) | 497.54 (16.76) | 499.80 (16.76) | 0.612 | 0.375 |
| Right | 468.29 (9.99) | 465.20 (8.04) | 464.01 (9.99) | 469.61 (8.04) | 0.977 | 0.829 |
| CA1 | ||||||
| Left | 678.61 (15.72) | 686.20 (16.18) | 734.85 (15.72) | 734.63 (16.18) | 0.064† | 0.424 |
| Right | 714.39 (15.91) | 731.81 (18.79) | 786.84 (15.91) | 776.89 (18.79) | 0.119 | 0.012* |
| CA2/3 | ||||||
| Left | 238.72 (12.66) | 240.03 (12.30) | 266.74 (12.66) | 268.08 (12.30) | 0.390 | 0.995 |
| Right | 273.97 (9.03) | 271.91 (8.77) | 294.69 (9.03) | 294.25 (8.77) | 0.347 | 0.788 |
| CA4 | ||||||
| Left | 313.37 (10.03) | 313.59 (9.16) | 339.90 (10.03) | 340.20 (9.16) | 0.409 | 0.990 |
| Right | 333.44 (12.77) | 334.74 (13.22) | 373.17 (12.77) | 370.26 (13.22) | 0.140 | 0.573 |
| GC-ML-DG | ||||||
| Left | 346.29 (9.99) | 347.79 (9.24) | 375.68 (9.99) | 373.81 (9.24) | 0.400 | 0.614 |
| Right | 364.66 (11.43) | 368.37 (11.87) | 402.29 (11.43) | 399.07 (11.87) | 0.085† | 0.378 |
| HATA | ||||||
| Left | 59.46 (2.85) | 60.61 (3.46) | 65.63 (2.85) | 64.92 (3.46) | 0.486 | 0.453 |
| Right | 63.67 (2.19) | 62.73 (2.46) | 66.94 (2.19) | 66.83 (2.46) | 0.523 | 0.631 |
| Fimbria | ||||||
| Left | 88.24 (4.83) | 88.38 (4.77) | 104.50 (4.83) | 106.14 (4.77) | 0.836 | 0.697 |
| Right | 86.02 (8.33) | 81.41 (7.80) | 98.90 (8.33) | 102.81 (7.80) | 0.201 | 0.055† |
| ML-DG | ||||||
| Left | 647.81 (13.35) | 655.02 (12.26) | 687.84 (13.35) | 685.65 (12.26) | 0.164 | 0.304 |
| Right | 679.17 (11.95) | 689.94 (13.56) | 712.41 (11.95) | 707.41 (13.56) | 0.224 | 0.106 |
| Hippocampal fissure | ||||||
| Left | 160.18 (10.97) | 157.78 (9.29) | 151.66 (10.97) | 156.91 (9.29) | 0.365 | 0.501 |
| Right | 159.09 (8.39) | 149.02 (8.84) | 153.92 (8.39) | 155.72 (8.84) | 0.159 | 0.370 |
| Hippocampal tail | ||||||
| Left | 592.66 (25.66) | 596.47 (25.11) | 570.66 (25.66) | 564.41 (25.11) | 0.661 | 0.426 |
| Right | 639.38 (29.88) | 630.33 (27.22) | 632.72 (29.88) | 625.14 (27.22) | 0.416 | 0.926 |
Repeated measures ANCOVA main effect of time and time by group interactions, controlling for intracranial volume and cumulative cannabis use (cones smoked) across the trial. Subicular complex is the sum of parasubiculum, presubiculum, and subiculum volumes.
*
p<0.05.
†
Trend-level significance.