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. Author manuscript; available in PMC: 2019 Apr 25.
Published in final edited form as: Eur J Med Chem. 2018 Mar 14;150:796–808. doi: 10.1016/j.ejmech.2018.03.035

Fig. 2.

Fig. 2

The presentative competitive binding curves of compounds 12b, 16b, and S1P for S1PR1. A CHO cell membrane containing recombinant human S1PR1 was used in a [32P]S1P competitive binding assay to measure the binding affinities. S1P (fitted IC50 = 1.4 ± 0.3 nM) 12b (fitted IC50 = 9.7 ± 1.6 nM); and 16b (fitted IC50 = 6.3 ± 1.3 nM).