Scheme 1.
Syntheses of 9a–e. Reagents and conditions: (a) NaH, 2-fluoroethan-1-ol, DMSO, 1 M HCl, RT; (b) hydroxylamine hydrochloride, NaHCO3, methanol, reflux; (c) TBTU, HOBt, DIPEA, DMF, RT-120 °C.
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