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. Author manuscript; available in PMC: 2019 Apr 25.
Published in final edited form as: Eur J Med Chem. 2018 Mar 14;150:796–808. doi: 10.1016/j.ejmech.2018.03.035

Table 2.

The IC50 values (mean ± SD) of S1P, 9a, 10c, 12b, and 16b toward other S1PRsa

Compd. IC50 (nM)
S1PR1 S1PR2 S1PR3 S1PR4 S1PR5
S1P 1.4 ± 0.3 3.6 ± 0.5 0.4 ± 0.2 151 ± 82 3.1 ± 1.1
9a 13.2 ± 3.2 > 1000 > 1000 > 1000 > 1000
10c 14.7 ± 1.7 > 1000 > 1000 > 1000 > 1000
12b 9.7 ± 1.6 > 1000 > 1000 > 1000 > 1000
16b 6.3 ± 1.3 > 1000 > 1000 > 1000 > 1000
a

IC50 values were determined at least 3 independent experiments, each run was performed in duplicate; Assays for compounds which showed no activity (IC50 > 1000 nM) were only repeated twice.