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. Author manuscript; available in PMC: 2019 Mar 22.
Published in final edited form as: J Med Chem. 2018 Mar 9;61(6):2589–2603. doi: 10.1021/acs.jmedchem.8b00136

Table 2.

HDAC1, 2, 3, and 6 Inhibitory Activity and in Vitro Antiproliferative Activity of 13e–13h and 18a

graphic file with name nihms955828u3.jpg
Compounds No. R IC50 (nM) EC50 (nM, MV4-11 cells)
HDAC1 HDAC2 HDAC3 HDAC6
13b graphic file with name nihms955828t8.jpg 63.28±10.24 287.1±38.2 8.50±0.89 >100000 138.7±23.5
13e graphic file with name nihms955828t9.jpg 9.54±1.34 28.04±4.12 1.41±0.57 >100000 34.7±4.2
13f graphic file with name nihms955828t10.jpg 80.19±10.29 209.0±30.5 12.44±15.26 >100000 1254±101
13g graphic file with name nihms955828t11.jpg 91.59±15.42 191.3±25.3 5.205±1.44 >100000 652.7±89.3
13h graphic file with name nihms955828t12.jpg 52.77±3.80 199.3±10.4 12.09±3.21 >100000 1687±239
18 graphic file with name nihms955828t13.jpg 28.88±2.78 283.3±43.6 2.816±0.76 >100000 243.0±48.2
a

IC50 and EC50 values are the mean of at least three experiments ± the standard error of the mean.