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. Author manuscript; available in PMC: 2019 Mar 22.
Published in final edited form as: J Med Chem. 2018 Mar 9;61(6):2589–2603. doi: 10.1021/acs.jmedchem.8b00136

Table 3.

Compound 13e Inhibitory Activity for HDAC1-11

HDAC classes subtype IC50 (nM)a
class I HDAC1 9.54 ± 1.34
HDAC2 28.04 ± 4.12
HDAC3 1.41 ± 0.57
HDAC8 557.3 ± 97.58
class IIa HDAC4 >50000
HDAC5 >50000
HDAC7 >50000
HDAC9 >50000
class IIb HDAC6 >50000
a

IC50 and EC50 values are the mean of at least three experiments ± the

standard error of the mean.