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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Oncogene. 2018 Jan 30;37(16):2079–2088. doi: 10.1038/s41388-017-0096-9

Figure 4. Schema of the proposed model in which MUC1-C integrates functions of PRC2, PRC1 and DNA methylation in the repression of tumor suppressor genes.

Figure 4

In this model, MUC1-C induces expression of the PRC2 components, EZH2, SUZ12 and EED, and thereby drives H3K27 trimethylation on target gene promoters 35. In addition, MUC1-C induces expression of the PRC1 components, BMI1, RING2 and RING1, and in turn the potential recruitment of PRC1 to H3K27me3 sites 36. In addition, MUC1-C activates DNMT1 and DNMT3b expression and changes in DNA methylation patterns 77. EZH2 and the H3K27me3 mark recruit DNMTs, leading to DNA methylation 11, 12. In concert with this model of gene repression, targeting MUC1-C with the downregulation of EZH2 35, BMI1 36, 75, and DNMT1/3b 77 is associated with induction of the target CDH1, CDKN2A, PTEN and BRCA1 TSGs.