Table 2.
Patient characteristics during ICU stay
| Characteristics | De-escalation | p | OR [95% CI] | |
|---|---|---|---|---|
| Yes (n = 38) | No (n = 152) | |||
| Multifocal colonization | 19 (50) | 115 (76) | 0.002 | 0.32 [0.15–0.67] |
| Negative yeast samples | 16 (42) | 30 (20) | 0.004 | 2.95 [1.4–6.3] |
| Empirical antifungal treatment | 12 (32) | 68 (45) | 0.14 | |
| Preemptive antifungal treatment | 4 (11) | 48 (32) | 0.008 | 0.26 [0.09–0.78] |
| Targeted antifungal treatment | 10 (26) | 36 (24) | 0.73 | |
| Proven bacterial infection | 10 (26) | 0 (0) | < 0.001 | NA |
| Apyrexia > 72 h | 37 (97) | 123 (81) | 0.013 | 8.7 [1.2–66] |
| Catecholamine withdrawal at 72 h | 29 (76) | 89 (59) | 0.026 | 2.57 [1.1–5.98] |
| Mechanical ventilation | 30 (79) | 142 (93) | 0.006 | 0.26 [0.09–0.73] |
| Antibiotic treatment | 38 (100) | 150 (99) | 0.96 | |
| Total parenteral nutrition | 18 (47) | 81 (53) | 0.51 | |
| Surgery | 21 (55) | 76 (50) | 0.56 | |
| Renal replacement therapy | 21 (55) | 76 (50) | 0.56 | |
| Shock | 31 (82) | 121 (80) | 0.79 | |
Data are N (%)
CI confidence interval, OR odds ratio