Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Apr 19;9:1551. doi: 10.1038/s41467-018-03998-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — Oxidative dysfunction by CRIF1 deficiency increases M1-like macrophages a Real-time PCR analysis of Crif1 in BMDMs from 8-week-old MacWT, MacHE, and MacHO mice. b, c Immunoblot analysis of OxPhos complex and CRIF1 expression in BMDMs from 8-week-old MacWT, MacHE, and MacHO mice. d, e Oxygen consumption rates (OCR) in BMDMs from 8-week-old MacWT, MacHE, and MacHO mice. CCCP: carbonyl cyanide m-chlorophenyl hydrazone. f Real-time PCR analysis of M1-related and M2-related genes in BMDMs from 8-week-old MacWT and MacHO mice. g, h Real-time PCR analysis of Il6 and Nos2 mRNA expression in the presence or absence of IFN-γ (10 ng/ml) and LPS (100 ng/ml). i, j Real-time PCR analysis of Arg1 and Ym1 mRNA expression in the presence or absence of IL-4 (20 ng/ml). k, l Immunoblot analysis of p38 phosphorylation after exposure to IFN-γ (10 ng/ml) and LPS (100 ng/ml) for 30 min. Data are expressed as means ± SEM and are representative of three independent experiments (n = 5 mice per group). *p < 0.05 or **p < 0.01 (two-tailed Student’s t test)