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. 2018 Apr 19;8:6264. doi: 10.1038/s41598-018-24657-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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BOLD FC within between networks. (A,B) zFC-matrices of 3 months (A) and 7 months (B) old APP^NL/NL (lower half of the matrix) and APP^NL-F/NL-F mice (upper half of the matrix). Color scale represents the z-score i.e. strength of FC between each pair of brain networks. (C,D) T-values representing the statistical group difference (lower half of the matrix) and binary matrix with statistically significant differences (upper half of the matrix) between APP^NL/NL and APP^NL-F/NL-F mice at 3 months (C) and 7 months of age (D). Color scale represents the T-values (twog-sample T-test). Abbreviations are listed in Table 1.