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. 2018 Apr 19;8:6264. doi: 10.1038/s41598-018-24657-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FC-map of the caudate putamen. Statistical zFC-maps of the right caudate putamen are shown for 3 and 7 months old APP^NL/NL and APP^NL-F/NL-F mice. Five slices of the zFC-maps are shown an anatomical T2-weighted MRI image and overlaid with the Franklin and Paxinos anatomical mouse brain atlas²⁹ with indication of the stereotactic coordinates a = interaural, b = bregma. Color scale represents the T-value (one-sample T-test), i.e. strength of FC of the right caudate putamen with all other voxels in the brain. Graphs show strength of FC as z-scores for FC between the caudate putamen and cingulate regions, and between the caudate putamen and hippocampus. *p < 0.05, **p < 0.01, ***p < 0.001, two-way ANOVA, corrected for multiple comparisons.