Table 1.
Baseline characteristics of subjects.
| Cerebral malaria | Severe malarial anaemia | Both cerebral malaria and severe malarial anaemia | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases (n = 43) | Uncomplicated malaria controls (n = 43) | Healthy controls (n = 40) | Cases (n = 24) | Uncomplicated malaria controls (n = 21) | Healthy controls (n = 21) | Cases (n = 11) | Uncomplicated malaria controls (n = 9) | Healthy controls (n = 11) | |
| Number female (%) | 18 (41.9%) | 18 (41.9%) | 15 (37.5%) | 8 (33.3%) | 11 (52.4%) | 11 (52.4%) | 9 (81.8%) | 2 (22.2%) | 8 (72.7%) |
| Age: mean + SD (months) | 30.9 ± 18.6 | 34.4 ± 21.4 | 30.9 ± 18.7 | 26.0 ± 17.8 | 22.7 ± 11.3 | 25.9 ± 17.8 | 31.3 ± 15.9 | 32.6 ± 19.6 | 32.4 ± 16.1 |
| Minimum/maximum | 4.7–79.5 | 9.3–97.7 | 6.6–76.2 | 7.3–78.5 | 7.4–51.2 | 6.2–68.4 | 11.0–64.7 | 6.5–77.1 | 9.0–65.0 |
| Ethnicity | |||||||||
| Dogon | 38 (88.4%) | 36 (83.7%) | 33 (82.5%) | 20 (83.3%) | 20 (95.2%) | 17 (81.0%) | 10 (90.9%) | 8 (88.9%) | 11 (100%) |
| Non-Dogon | 5 (11.6%) | 7 (16.2%) | 7 (17.5%) | 4 (16.7%) | 1 (4.8%) | 4 (19.0%) | 1 (9.1%) | 1 (11.1%) | 0 |
| Haemoglobin status1 | |||||||||
| Hb AA | 35 (87.5%) | 31 (75.6%) | 30 (78.9%) | 24 (100%) | 17 (81.0%) | 19 (90.5%) | 8 (80.0%) | 5 (55.6%) | 7 (63.6%) |
| Hb AC | 5 (12.5%) | 9 (22.0%) | 3 (7.9%) | 0 | 3 (14.3%) | 0 (4.8%) | 1 (10.0%) | 2 (22.2%) | 2 (18.2%) |
| Hb AS | 0 | 0 | 5 (13.2%) | 0 | 1 (4.8%) | 1 (4.8%) | 1 (10.0%) | 1 (11.1%) | 2 (18.2%) |
| Hb CC | 0 | 1 (2.4%) | 0 | 0 | 0 | 1 (4.8%) | 0 | 1 (11.1%) | 0 |
| Parasitemia: median (p/μL) | 80,000 | 6,500 | 0 | 83,112.5 | 9,825 | 0 | 37,125 | 9,300 | 0 |
| 25th–75th percentiles | 14,662.5–549,487.5 | 1,937.5–19,525 | — | 17,600–520,781.25 | 2,850–28,725 | — | 15,337.5–96,750 | 1,025–30,675 | — |
| Haemoglobin: mean ± SD, g/dL | 8.2 ± 2.1 | 8.9 ± 1.8 | 10.3 ± 1.6 | 4.3 ± 0.8 | 8.9 ± 1.6 | 9.6 ± 1.6 | 4.0 ± 0.5 | 9.1 ± 1.4 | 11.1 ± 1.1 |
| Minimum/maximum | 5.1–12.7 | 5.3–13.0 | 6.9–13.4 | 2.0–5.0 | 6.4–12.2 | 6.2–13.0 | 2.6–4.6 | 7.0–10.7 | 9.4–12.6 |
| Blantyre Coma Scale: mean | 1.3 | 5 | 5 | 4.7 | 5 | 5 | 1.5 | 5 | 5 |
| 25th–75th percentiles | 1–2 | 5–5 | 5–5 | 5–5 | 5–5 | 5–5 | 1–2 | 5–5 | 5–5 |
| Minimum/maximum | 0–2 | 5–5 | 5–5 | 3–5 | 5–5 | 5–5 | 0–2 | 5–5 | 5–5 |
| Mortality (%) | 6 (14.0%) | 0 | 0 | 6 (25%) | 0 | 0 | 3 (27.3%) | 0 | 0 |
| Convalescent samples (n) | 27 | — | — | 12 | — | — | 0 | — | — |
Hb, haemoglobin; SD, standard deviation.
1Haemoglobin status was not successfully determined for all subjects.