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. 2018 Apr 13;11:126. doi: 10.3389/fnmol.2018.00126

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Copyright © 2018 Grégoire, Tobin, Goldenstein, Samarut, Leclerc, Aumont, Drapeau, Fulton and Fernandes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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“Core” running-induced transcriptomic changes. (A) Venn diagram showing the relationship between significantly modulated genes in the L-RUN and H-RUN groups, focusing on the 53 “Core” running genes that were modulated in both groups (highlighted). Bio-informatic analyses of Core running genes was performed by gene set enrichment analysis for GO Biological Processes (B), GO Cellular Components (C), GO Molecular Functions (D), and KEGG and Reactome pathways (E). For each of the GO categories, the top 10 enriched gene sets are shown plotted against their –log10(p-value). Gene sets in bold had likewise shown enrichment for genes modulated in the RUN group (Figure 4).