Figure 1.

Induction CTX impairs natural killer (NK) cell maturation and ADCC functions. Flow cytometry analysis of the indicated parameters in peripheral NK cells from HV and multiple myeloma patients after induction/consolidation CTX (post-Velcade Revlimid Dexamethasone). (A,B) Parameters were clustered in functional categories “antitumor function,” “activation markers,” and “cell surface receptors” as labeled and displayed as heatmaps (black dots are patients who received Velcade Revlimid Dexamethasone and blue dots are patients who received stem-cell transplantation). Stars summarize significance level of the p-values adjusted for multiple testing by the Benjamini–Hochberg method. These p-values were obtained using logistic regression models, which compare each patient group with the HD group. Significance codes: 0 “***” 0.001 “**” 0.01 “*” 0.05 “ ” 1.