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. 2018 Apr 13;10:102. doi: 10.3389/fnagi.2018.00102

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Copyright © 2018 Grand Moursel, van Roon-Mom, Kiełbasa, Mei, Buermans, van der Graaf, Hettne, de Meijer, van Duinen, Laros, van Buchem, ‘t Hoen, van der Maarel and van der Weerd.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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qPCR analysis of (A) three up-regulated genes (HSPA1A, NPTX2, and PDYN) and (B) two down-regulated genes (GPD1 and CX3CR1). Transcript levels of HCHWA-D samples were not following a normal distribution (data not shown). HSPA1A and PDYN were found significantly up-regulated (MW test, p = 0.006^∗∗ and p = 0.040^∗, respectively). For GPD1, significance was reached upon removal of the greatest outlier (t-test, p = 0.030^∗; S_27-28 outlier identified with the ROUT method, Q = 1%; data not shown), no significant outliers found for CX3CR1. Transcript expression levels were normalized with two reference gene, n = 9. (C) TBP normalization control was not significantly different (t-test, p = 0.32). ^∗p < 0.05 and ^∗∗p < 0.01. RNA-seq samples code are used to identify greatest outlier.