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. 2018 Apr 13;10:102. doi: 10.3389/fnagi.2018.00102

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Copyright © 2018 Grand Moursel, van Roon-Mom, Kiełbasa, Mei, Buermans, van der Graaf, Hettne, de Meijer, van Duinen, Laros, van Buchem, ‘t Hoen, van der Maarel and van der Weerd.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dysregulated pathways in HCHWA-D. (A) Significantly dysregulated pathways in HCHWA-D DEG subset and associated genes identifiers in GeneTrail2 v1.5 (with fold change input; ranked on statistical significance except for the combined HD, AD, and PD categories). Depleted pathways (green arrows) are over-represented by down-regulated genes and enriched pathways (red arrows) are over-represented by up-regulated genes. Text color codes distinguish pathways originating from KEGG (orange) or Reactome (purple) databases. (B) Schematic representation of known interactions between genes of the ECM-related pathways. Representation of high confidence interactions with MCL clustering in String interaction database (line thickness indicates the strength of data support).