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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Epilepsy Behav. 2017 Jun 23;73:214–235. doi: 10.1016/j.yebeh.2017.05.040

Table 1.

Effects of intra-strain differences in Wistar and Sprague-Dawley rats on seizure threshold, induction of SE, and development of kindling or epilepsy in three models of temporal lobe epilepsy. N.d. = not determined.

Rat strain Amygdala kindling
(Honndorf et al. [40])		 BLA-SE
(Langer et al. [19])		 Lithium/pilocarpin SE
(Brandt et al. [37])
Pre-
kindling
ADT		 Post-
kindling
ADT		 ADD to
stage 5		 SE
induction		 SE type
III		 SRS Hippocampal
damage		 SE
induction		 SRS Hippocampal
damage
Wistar
1. Harlan-Winkelmann (Hsdcpb:WU) No intra-strain differences No intra-strain differences Not different from 3 56/77
(73%)		 23/77
(30%)		 6/6
(100%)		 n.d. 116/170
(68%)		 37/41
(90%)		 n.d.
2. Charles River (Crl:WI (Han)) No intra-strain differences No intra-strain differences Significantly higher vs. 1 and 3 n.d. n.d. n.d. n.d. n.d. n.d. n.d.
3. Janvier (RiHan:WI) No intra-strain differences No intra-strain differences Not different from 1 5/7
(71%)		 0/7
(0%)		 1/1
(100%)		 n.d. n.d. n.d. n.d.
4. Taconic (HanTac:WH) n.d. n.d. n.d. 6/12
(50%)		 0/121
(0%)		 2/2
(100%)		 n.d. 0/172
(0%)		 n.d. n.d.
Sprague-Dawley (SD)
1. Harlan-Winkelmann (Hsd:SD) n.d. n.d. n.d. 236/255
(93%)		 145/255
(57%)		 75/81
(93%)		 + 34/46
(74%)		 7/7
(100%)		 +
2. Harlan NL (Hsd:SD) n.d. n.d. n.d. 48/49
(98%)		 32/49
(65%)		 10/14
(71%)		 + 7/183
(39%)		 3/7
(43%)		 +
3. Charles River (Crl:CD (SD)) n.d. n.d. n.d. 30/37
(81%)		 14/374
(38%)		 9/205
(45%)		 − 10/293
(34%)		 11/13
(85%)		 +
4. Janvier (RjHan:SD) n.d. n.d. 7/114
(64%)		 6/11
(55%)		 3/5
(60%)		 ± n.d. n.d. n.d.
5. Taconic (NTac:SD) n.d. n.d. n.d. 10/10
(100%)		 5/10
(50%)		 8/9
(89%)		 ± n.d. n.d. n.d.
1

P<0,05 vs. 1 (Wistar);

2

P<0.0001 vs. 1 (Wistar);

3

P<0.05 vs. 1 (SD);

4

P<0.01 vs. 1 (SD);

5

P<0.0001 vs. 1 (SD)