Table 2.
Efficiency of non-HC infection by AAV injection through canalostomy
AAV1 | Sensory | 42.7 ± 22.1 | 35.1 ± 12.0 | 19.1 ± 4.2 | 13.3 ± 2.2 | 19.8 ± 3.9 | 11.9 ± 1.6 | 8.0 ± 11.8 |
Non-sensory | 25.7 ± 25.2 | 11.3 ± 11.7 | 5.2 ± 7.3 | 5.3 ± 5.9 | 4.8 ± 4.7 | 3.9 ± 3.4 | 0 | |
AAV2 | sensory | 6.0 ± 5.5 | 11.1 ± 10.5 | 4.5 ± 3.0 | 1.4 ± 1.3 | 0.4 ± 0.7 | 0 | 0.4 ± 0.5 |
Non-sensory | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
AAV2/Anc80L65 | Sensory | 13.9 ± 6.8 | 14.6 ± 6.2 | 8.9 ± 7.9 | 7.7 ± 7.3 | 5.4 ± 4.7 | 5.3 ± 6.8 | 4.0 ± 4.7 |
Non-sensory | 33.0 ± 16.2 | 37.5 ± 13.5 | 30.6 ± 12.6 | 33.0 ± 12.5 | 25.5 ± 8.3 | 19.8 ± 16.5 | 25.9 ± 21.5 | |
AAV6.2 | Sensory | 30.7 ± 5.1 | 67.3 ± 28.2 | 42.3 ± 10.6 | 53.0 ± 15.0 | 51.3 ± 7.8 | 60.0 ± 31.8 | 31.0 ± 29.5 |
Non-sensory | 9.3 ± 4.3 | 13.9 ± 8.3 | 0 | 0 | 0 | 0 | 0 | |
AAV8 | Sensory | 12.0 ± 6.3 | 10.2 ± 8.2 | 22.1 ± 11.4 | 14.0 ± 7.3 | 17.3 ± 12.1 | 6.8 ± 7.6 | 14.5 ± 10.0 |
Non-sensory | 17.9 ± 2.6 | 16.8 ± 5.2 | 20.8 ± 5.6 | 27.8 ± 4.5 | 26.0 ± 2.0 | 19.6 ± 7.4 | 20.3 ± 9.1 | |
AAV9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
AAVrh.39 | Sensory | 16.8 ± 12.3 | 11.6 ± 7.7 | 7.9 ± 1.3 | 1.7 ± 0.3 | 3.2 ± 0.9 | 3.0 ± 1.5 | 2.4 ± 1.0 |
Non-sensory | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
AAVrh.43 | Sensory | 23.8 ± 1.3 | 22.0 ± 2.0 | 26.7 ± 0.3 | 17.4 ± 7.7 | 22.5 ± 6.1 | 21.4 ± 3.0 | 23.7 ± 5.8 |
Non-sensory | 42.1 ± 5.9 | 31.0 ± 13.0 | 35.4 ± 13.1 | 21.4 ± 19.0 | 22.0 ± 27.5 | 12.1 ± 15.5 | 10.0 ± 8.6 |
The infected cells are indicated by the number per 200 μm.