Table 1.

Hematologic Abnormalities in SHIVnef-Infected Macaques

NEPRC
	NEPRC 1, (12 WPI)	NEPRC 2, (16 WPI)	NEPRC 4, (27 WPI)	NEPRC 5, (80 WPI)
White blood cells	→	↓	→	→
Red blood cells	→	→	→	→
Hemoglobin	→	→	→	→
Hematocrit	→	→	→	→
Platelets	→	↓	→	↓
Lymphocytes	→	↓	↓ (p < 0.05)	→

CNPRC
	CNPRC 1, (12 WPI)	CNPRC 2, (13 WPI)	CNPRC 3, (24 WPI)	CNPRC 4, (37 WPI)	CNPRC 5, (50 WPI)	CNPRC 6, (62 WPI)
White blood cells	→		→	→	→	↓
Red blood cells	→	↓	↓	↓	→	↓(p < 0.05)
Hemoglobin	↓	↓(p < 0.01)	↓(p < 0.001)	↓(p < 0.01)	→	↓
Hematocrit	↓	↓(p < 0.01)	↓	↓(p < 0.01)	→	↓(p < 0.01)
Platelets	↑	→	↓	↑	↓	↓
Lymphocytes	→	→	→	↓(p < 0.001)	→	↓
Mean cell hemoglobin	↓ (p < 0.01)	↓(p < 0.01)	↓	↓(p < 0.001)	→	→
Neutrophils	↑	↓	↑	↑(p < 0.01)	→	↓
Monocytes	→	→	→	↑	→	→
Eosinophils	↑	→	→	↑	→	→

Longitudinal complete blood count (CBC) in SHIVnef-infected macaques at NEPRC (top panel) and CNPRC (bottom panel). Macaque IDs are shown, with the times postinfection in parenthesis. CBC data were analyzed relative to normal CBC values in male Rhesus macaques (Gill et al. 2012 and Chen et al. 2009). Values were categorized as blood cell abnormalities if the median values exceeded the normal intervals (up arrows) or were below the normal intervals (down arrows). Median values within the normal intervals are shown as horizontal arrows. Data were analyzed by one-way ANOVA with Dunn's multiple comparison tests to compare CBC values of each macaque with the rest of his mates. p-Values were determined with Gaussian approximations and are shown only for statistically significant CBC values. Statistical significance was set at p < 0.05.

NEPRC, New England National Primate Research Center; CNPRC, California National Primate Research Center; WPI, weeks postinfection; SHIVnef, chimeric simian-human immunodeficiency virus containing HIV nef.