Table 2.
Partial correlations (Spearman) between apathy scores (AES) and 1H-MRS metabolites, controlling for gender, depression scores (GDS non-apathy), and proportion of white matter (WM) and CSF in the voxel.
| N (aMCI_A/aMCI_NA/CN) | R | p (unc) | p (fdr) | |
|---|---|---|---|---|
| Posterior cingulate cortex (PCC) | ||||
| NAA | 46 (8/18/20) | 0.015 | 0.36 | 0.55 |
| Cho | 46 (8/18/20) | –0.39 | 0.01 | 0.07 |
| mI | 45 (8/18/19) | –0.12 | 0.46 | 0.55 |
| Cr | 46 (8/18/20) | –0.16 | 0.31 | 0.55 |
| Glx | 46 (8/18/20) | 0.05 | 0.76 | 0.76 |
| NAA/mI | 45 (8/18/19) | 0.14 | 0.37 | 0.55 |
| Dorsal anterior cingulate cortex (DACC) | ||||
| NAA | 46 (8/18/20) | 0.17 | 0.28 | 0.85 |
| Cho | 46 (8/18/20) | 0.01 | 0.99 | 0.99 |
| mI | 42 (7/17/18) | 0.06 | 0.74 | 0.99 |
| Cr | 46 (8/18/20) | 0.06 | 0.69 | 0.99 |
| Glx | 41 (8/15/18) | 0.32 | 0.05 | 0.32 |
| NAA/mI | 42 (7/17/18) | 0.01 | 0.96 | 0.99 |
| Right dorsolateral prefrontal cortex (R-DLPFC) | ||||
| NAA | 43 (7/16/20) | –0.04 | 0.79 | 0.99 |
| Cho | 43 (7/16/20) | –0.37 | 0.02 | 0.13 |
| mI | 38 (7/15/16) | <0.01 | 0.99 | 0.99 |
| Cr | 43 (7/16/20) | 0.08 | 0.61 | 0.99 |
| Glx | 41 (7/15/19) | 0.03 | 0.88 | 0.99 |
| NAA/mI | 38 (7/15/16) | <0.01 | 0.99 | 0.99 |
| Right temporo-parietal cortex (R-TPC) | ||||
| NAA | 45 (8/18/19) | –0.11 | 0.48 | 0.48 |
| Cho | 45 (8/18/19) | -0.53 | 0.0003 | 0.002 |
| mI | 45 (8/18/19) | -0.37 | 0.016 | 0.049 |
| Cr | 45 (8/18/19) | –0.15 | 0.36 | 0.44 |
| Glx | 45 (8/18/19) | –0.19 | 0.23 | 0.35 |
| NAA/mI | 45 (8/18/19) | 0.28 | 0.08 | 0.16 |
AES, Apathy Evaluation Scale; GDS, Geriatric Depression Scale; N, sample size; aMCI_A, aMCI with apathy; aMCI_NA, aMCI without apathy; CN, cognitively normal matched controls; NAA, N-acetylaspartate; Cho, Glycerophosphocholine and phosphocholine; mI, myo-inositol; Cr, Creatine and phosphocreatine; Glx, Glutamate and glutamine. Significant values are given in bold. p (unc), uncorrected p-values; p (fdr), false discovery rate corrected p-values.