Table 3.
Differences in metabolite levels between aMCI and cognitively normal controls.
| PCC | DACC | R-DLPFC | R-TPC | |
|---|---|---|---|---|
| NAA | 1.64 (5,40), p = 0.17 | 6.50 (5,40), p < 0.01 | 1.41 (5,38), p = 0.24 | 0.21 (5,39), p = 0.95 |
| t = 0.93, p = 0.36 | ||||
| Cho | 1.00 (5,40), p = 0.43 | 0.23 (5,40), p = 0.95 | 1.26 (5,38), p = 0.30 | 0.93 (5,39), p = 0.47 |
| mI | 0.92 (5,39), p = 0.48 | 0.16 (5,36), p = 0.97 | 0.86 (5,32), p = 0.52 | 1.44 (5,39), p = 0.23 |
| Cr | 3.38 (5,40), p = 0.01 | 0.29 (5,40), p = 0.91 | 1.11 (5,38), p = 0.37 | 0.72 (5,39), p = 0.61 |
| t = -1.78, p = 0.08 | ||||
| Glx | 0.63 (5,40), p = 0.68 | 1.57 (5,35), p = 0.19 | 0.86 (5,36), p = 0.52 | 0.41 (5,39), p = 0.84 |
| NAA/mI | 1.98 (5,39), p = 0.10 | 0.28 (5,36), p = 0.92 | 0.72 (5,32), p = 0.61 | 1.09 (5,39), p = 0.38 |
Numbers given are the value of F-test of ANCOVA for group differences and (uncorrected) significance values with fraction of CSF and WM, gender, and Geriatric Depression Scale (GDS) non-apathy score as covariates. When significant, the value of the t-test for difference between aMCI and control groups is given along with significance in bold. aMCI, amnestic mild cognitive impairment; NAA, N-acetylaspartate; Cho, glycerophosphocholine and phosphocholine; mI, myo-inositol; Cr, creatine and phosphocreatine; Glx, glutamate and glutamine; PCC, posterior cingulate cortex; .DACC, dorsal anterior cingulate cortex; R-DLPFC, right dorsolateral prefrontal cortex; R-TPC, right temporo-parietal cortex.