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. 2018 Apr 20;5(2):ENEURO.0007-18.2018. doi: 10.1523/ENEURO.0007-18.2018

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Copyright © 2018 Tennyson et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 2. — Putative DA firing was higher for GO trials during the response period but higher for STOPs at the time of reward. A, Single-cell example of a putative DA neuron aligned to port exit that fired more for GO trials (left) than STOP trials (right). B, The same single-cell example from A aligned to reward delivery, showing higher firing to reward on STOP trials (right) compared to GO trials (left). C, The same single-cell example from A, B aligned to reward delivery and zoomed in on the reward response, showing higher firing on STOP trials (right) compared to GO trials (left). D, The same single-cell example from A, B zoomed in on the response following well entry, showing higher firing on correct STOP trials (left) compared to STOP errors (right). E–H, Population average histograms of putative DA neurons plotted over trial time for GO (blue), STOP (red), and STOP error (dashed) trials while aligning to multiple events (n = 85). Activity is aligned to initial GO cue (E), port exit (F), well entry (G), and reward delivery (H). E, At the time of the initial cue, firing rate increases rapidly for all trial types. F, During the response epoch (the period from port exit to well entry, when the STOP cue was illuminated on STOP trials), firing was significantly higher on GO trials compared to STOP trials. G, During the post-response epoch (the 800 ms period following well entry), firing was significantly lower on STOP errors compared to STOP corrects. H, During the reward epoch (500 ms period after reward delivery), firing was significantly higher on STOP trials than GO trials. Error trials are excluded since reward is not delivered on errors. I–K, Population average distributions for significant effects described above. Arrows depict direction of distribution shift for significant effects. Black bars represent the number of neurons that showed a significant difference between GO and STOP corrects (I, K) and correct and incorrect STOP trials (J; Wilcoxon, p < 0.05). Distributions are determined to be significantly different from zero via Wilcoxon. I, K, Firing rate during the response and reward epoch were compared during correct STOPs and GOs by computing a trial type index (STOP correct – GO correct/STOP correct + GO correct). J, Firing rate during the post-response epoch was compared in correct and incorrect STOP trials (STOP error – STOP correct/STOP error + STOP correct).