Table 2.
Distribution of BCMO1 single nucleotide polymorphisms and their associations with lung cancer
| Locus | Case (n = 1166) | Control (n = 1179) | Unadjusted OR | Adjusted OR* | Ptrend value |
|---|---|---|---|---|---|
| 95% CI | 95% CI | ||||
| rs6564851(PHWE = 0.57) | 1097 | 1102 | 0.729 | ||
| GG | 743 (67.7%) | 724 (65.7%) | 1 | 1 | |
| GT | 310 (28.3%) | 342 (31.0%) | 0.883 (0.734–1.062) | 0.922 (0.754–1.128) | |
| TT | 44 (4.0%) | 36 (3.3%) | 1.191 (0.758–1.872) | 1.311 (0.805–2.134) | |
| GT + TT | 354 (32.3%) | 378 (34.3%) | 0.913 (0.764–1.090) | 0.959 (0.791–1.163) | |
| rs12934922(PHWE = 0.88) | 1121 | 1146 | 0.672 | ||
| AA | 839 (74.8%) | 861 (75.1%) | 1 | 1 | |
| AT | 261 (23.3%) | 264 (23.0%) | 1.015 (0.834–1.234) | 0.955 (0.772–1.182) | |
| TT | 21 (1.9%) | 21 (1.8%) | 1.026 (0.556–1.893) | 0.813 (0.424–1.561) | |
| AT+TT | 282 (25.2%) | 285 (24.8%) | 1.015 (0.840–1.228) | 0.944 (0.768–1.160) | |
| rs7501331(PHWE = 0.09) | 1060 | 1084 | 0.117 | ||
| CC | 707 (66.7%) | 696 (64.2%) | 1 | 1 | |
| CT | 308 (29.1%) | 334 (30.8%) | 0.908 (0.753–1.094) | 0.862 (0.704–1.056) | |
| TT | 45 (4.2%) | 54 (5.0%) | 0.820 (0.545–1.235) | 0.829 (0.531–1.294) | |
| CT + TT | 353 (33.3%) | 388 (35.8%) | 0.896 (0.749–1.070) | 0.858 (0.707–1.041) |
*adjusted by incomes, occupation, education, family history of lung cancer, history of lung diseases, environmental tobacco smoke, smoking status, BMI