Table 5.
Associations between dietary patterns and lung cancer risk by genotype at 3 SNPs
| Dietary patterns | Cases/controls | Adjusted OR (95% CI) | Cases/controls | Adjusted OR (95% CI) | P for interaction |
|---|---|---|---|---|---|
| rs6564851:GG | rs6564851:GT + TT | ||||
| High quality protein | Ptrend = 0.655 | Ptrend = 0.001 | 0.019 | ||
| Q1(low) | 186/169 | 1.00(ref) | 80/111 | 1.00(ref) | |
| Q2 | 195/180 | 1.112 (0.807–1.531) | 76/99 | 1.186 (0.758–1.855) | |
| Q3 | 176/184 | 0.999 (0.722–1.381) | 97/82 | 1.869 (1.200–2.910) | |
| Q4(high) | 186/191 | 1.120 (0.811–1.547) | 98/86 | 1.870 (1.206–2.900) | |
| Fruits and vegetables | Ptrend < 0.001 | Ptrend < 0.001 | 0.792 | ||
| Q1(low) | 386/186 | 1.00(ref) | 181/91 | 1.00(ref) | |
| Q2 | 162/182 | 0.413 (0.304–0.559) | 82/94 | 0.511 (0.339–0.770) | |
| Q3 | 114/176 | 0.300 (0.216–0.416) | 53/99 | 0.280 (0.179–0.437) | |
| Q4(high) | 81/180 | 0.217 (0.153–0.309) | 38/94 | 0.227 (0.140–0.367) | |
| Cereals and meat | Ptrend = 0.036 | Ptrend = 0.541 | 0.1 | ||
| Q1(low) | 188/165 | 1.00(ref) | 89/119 | 1.00(ref) | |
| Q2 | 203/191 | 0.857 (0.622–1.181) | 91/85 | 1.230 (0.797–1.899) | |
| Q3 | 170/185 | 0.726 (0.523–1.008) | 92/89 | 1.163 (0.757–1.787) | |
| Q4(high) | 182/183 | 0.729 (0.525–1.012) | 82/85 | 1.163 (0.748–1.809) | |
| Frugal pattern | Ptrend = 0.028 | Ptrend = 0.445 | 0.371 | ||
| Q1(low) | 165/192 | 1.00(ref) | 83/86 | 1.00(ref) | |
| Q2 | 173/183 | 1.016 (0.734–1.408) | 59/95 | 0.569 (0.354–0.915) | |
| Q3 | 174/176 | 1.053 (0.759–1.461) | 85/93 | 0.785 (0.499–1.234) | |
| Q4(high) | 231/173 | 1.423 (1.036–1.956) | 127/104 | 1.034 (0.672–1.592) | |
| rs12934922:AA | rs12934922:AT+TT | ||||
| High quality protein | Ptrend = 0.065 | Ptrend = 0.119 | 0.69 | ||
| Q1(low) | 203/213 | 1.00(ref) | 65/79 | 1.00(ref) | |
| Q2 | 209/221 | 1.132 (0.844–1.519) | 72/64 | 1.400 (0.838–2.339) | |
| Q3 | 203/214 | 1.180 (0.877–1.588) | 78/67 | 1.610 (0.965–2.686) | |
| Q4(high) | 224/213 | 1.321 (0.984–1.773) | 67/75 | 1.470 (0.878–2.463) | |
| Fruits and vegetables | Ptrend < 0.001 | Ptrend < 0.001 | 0.447 | ||
| Q1(low) | 426/214 | 1.00(ref) | 156/73 | 1.00(ref) | |
| Q2 | 185/227 | 0.430 (0.326–0.567) | 59/65 | 0.432 (0.266–0.701) | |
| Q3 | 135/210 | 0.309 (0.229–0.416) | 38/74 | 0.263 (0.156–0.443) | |
| Q4(high) | 93/210 | 0.224 (0.162–0.309) | 29/73 | 0.216 (0.124–0.376) | |
| Cereals and meat | Ptrend = 0.701 | Ptrend = 0.035 | 0.129 | ||
| Q1(low) | 206/216 | 1.00(ref) | 77/74 | 1.00(ref) | |
| Q2 | 217/226 | 0.903 (0.674–1.210) | 82/59 | 1.275 (0.767–2.118) | |
| Q3 | 200/212 | 0.864 (0.641–1.164) | 68/77 | 0.836 (0.510–1.370) | |
| Q4(high) | 216/207 | 0.953 (0.707–1.283) | 55/75 | 0.624 (0.369–1.053) | |
| Frugal pattern | Ptrend = 0.079 | Ptrend = 0.725 | 0.619 | ||
| Q1(low) | 179/217 | 1.00(ref) | 72/66 | 1.00(ref) | |
| Q2 | 191/223 | 0.933 (0.689–1.263) | 55/69 | 0.701 (0.412–1.193) | |
| Q3 | 1194/207 | 0.938 (0.691–1.273) | 71/77 | 0.821 (0.492–1.368) | |
| Q4(high) | 275/214 | 1.287 (0.960–1.727) | 84/73 | 1.031 (0.627–1.695) | |
| rs7501331:CC | rs7501331:CT + TT | ||||
| High quality protein | Ptrend = 0.097 | Ptrend = 0.134 | 0.902 | ||
| Q1(low) | 180/181 | 1.00(ref) | 77/89 | 1.00(ref) | |
| Q2 | 172/177 | 1.139 (0.826–1.571) | 92/101 | 1.189 (0.751–1.883) | |
| Q3 | 182/168 | 1.323 (0.957–1.827) | 81/95 | 1.089 (0.678–1.748) | |
| Q4(high) | 173/170 | 1.269 (0.917–1.756) | 103/103 | 1.483 (0.934–2.354) | |
| Fruits and vegetables | Ptrend < 0.001 | Ptrend < 0.001 | 0.487 | ||
| Q1(low) | 359/173 | 1.00(ref) | 191/101 | 1.00(ref) | |
| Q2 | 160/175 | 0.464 (0.341–0.630) | 65/99 | 0.372 (0.241–0.574) | |
| Q3 | 115/182 | 0.291 (0.210–0.402) | 51/86 | 0.332 (0.209–0.528) | |
| Q4(high) | 73/166 | 0.212 (0.147–0.305) | 46/102 | 0.274 (0.172–0.435) | |
| Cereals and meat | Ptrend = 0.110 | Ptrend = 0.948 | 0.44 | ||
| Q1(low) | 169/177 | 1.00(ref) | 100/102 | 1.00(ref) | |
| Q2 | 202/179 | 1.083 (0.786–1.494) | 77/89 | 0.778 (0.493–1.229) | |
| Q3 | 176/166 | 1.005 (0.725–1.395) | 84/104 | 0.694 (0.443–1.088) | |
| Q4(high) | 160/174 | 0.769 (0.550–1.074) | 92/93 | 1.032 (0.662–1.610) | |
| Frugal pattern | Ptrend = 0.014 | Ptrend = 0.727 | 0.253 | ||
| Q1(low) | 150/180 | 1.00(ref) | 88/92 | 1.00(ref) | |
| Q2 | 153/175 | 0.979 (0.700–1.370) | 76/100 | 0.709 (0.446–1.127) | |
| Q3 | 180/170 | 1.172 (0.842–1.630) | 71/95 | 0.651 (0.405–1.048) | |
| Q4(high) | 224/171 | 1.433 (1.036–1.982) | 118/101 | 1.055 (0.682–1.632) | |