Table 2.
CCR5 promoter variant (wild type/deletion) allele and genotype frequencies in serologically MV positive and negative sheep
| Breed subset | MV status |
CCR5 allele frequency (n chromosomes) |
P value | CCR5 genotype frequency | P value | ||
|---|---|---|---|---|---|---|---|
| (n sheep) | (n sheep) | (n sheep) | (n sheep) | ||||
| del | wt | del/del | del/wt, wt/wt | ||||
| All (521) | Negative (206) | 0.19 (77) | 0.81 (335) | 0.021 | 0.04 (8) | 0.96 (198) | 0.519 |
| Positive (315) | 0.13 (85) | 0.87 (545) | 0.03 (9) | 0.97 (306) | |||
| TEX-x (337) | Negative (96) | 0.14 (26) | 0.86 (166) | 0.177 | 0.02 (2) | 0.98 (94) | 0.321 |
| Positive (241) | 0.10 (49) | 0.90 (433) | 0.01 (2) | 0.99 (239) | |||
| GBM (39) | Negative (35) | 0.37 (26) | 0.63 (44) | 0.253 | 0.11 (4) | 0.89 (31) | 0.321 |
| Positive (4) | 0.63 (5) | 0.37 (3) | 0.25 (1) | 0.75 (3) | |||
| MLS-x (125) | Negative (62) | 0.17 (21) | 0.83 (103) | 0.135 | 0.02 (1) | 0.98 (61) | 0.114 |
| Positive (63) | 0.25 (31) | 0.75 (95) | 0.10 (6) | 0.90 (57) | |||
| EFM–LAC (20) | Negative (13) | 0.15 (4) | 0.85 (22) | 0.278 | 0.08 (1) | 0.92 (12) | 1.000 |
| positive (7) | 0.00 (0) | 1.00 (14) | 0.00 (0) | 1.00 (7) | |||
del: deletion, wt: wild type, TEX-x: purebred and crossbred German Texel sheep, GBM: purebred German Blackheaded Mutton sheep, MLS-x: purebred and crossbred Merinoland sheep, EFM–LAC: East Friesian milk and Lacaune sheep and crosses of both breeds.