Table 2.

Univariate and multivariate models for OS with BM in mTNBC patients (n = 127)

		Univariate			Multivariate
Factor	No.	Median	95% CI	P	HR	95% CI	P
Age				0.55
≤ 40	29	6.4	1.7–11.1
> 40	98	7.3	6.1–8.5
DFI				0.33
≤ 1 y	31	7.6	4.7–10.5
> 1 y	76	7.6	4.5–11.7
IV	20	5.4
KPS				0.000			0.07
70–100	109	7.6	4.7–10.4		1.81
40–60	18	1.7	0.2–3.4
Recurrent BM				0.008			0.01
First	32	17.3	9.2–25.3		2.21	1.18–4.17
Subsequent	95	6.3	4.5–8.0
Number of intracranial metastases				0.002			0.001
> 3	58	5.4	2.1–8.7		2.37	1.47–3.80
≤ 3	69	10.2	6.3–14.1
Symptomatic brain metastasis				0.02			0.01
Presence	76	5.5	2.8–8.2		1.92	1.13–3.27
Absence	51	8.7	3.0–16.7
Meninges involvement				0.01			0.48
Yes	14	3.2	0.9–5.4		1.32	0.61–2.83
No	113	7.6	4.8–10.3
Brain-directed treatment				0.001			0.002
Not performed	29	3.7	0.2–7.7		2.30	1.32–3.92
Performed	98	9.5	6.3–12.7
Extracranial metastasisa				0.002			0.02
Under-control	37	9.8	5.8–13.8		1.78	1.13–2.92
Out-of-control	65	3.6	2.2–4.9

^a103 patients died