Table 3.

Association between human-extracted image phenotype and computer-extracted image phenotype

Human-extracted assessment	Computer-extracted feature	p Value
Lesion size	Effective diameter	<10−12
	Surface area-to-volume ratio	<10−12
	Maximum linear size	<10−12
	Lesion volume	<10−12
Shape	Sphericity	5.65 × 10−5
	Irregularity	0.00398
	Surface area-to-volume ratio	0.363
Internal enhancement	Contrast	0.378
	Correlation	0.409
	Difference in entropy	0.353
	Difference variance	0.191
	Energy	0.186
	Entropy	0.194
	Inverse difference moment	0.466
	IMC1	0.328
	IMC2	0.340
	Maximum correlation coefficient	0.336
	Sum average	0.151
	Sum entropy	0.336
	Sum variance	0.702
	Sum of squares	0.297
Degree of margin spiculation	Mean margin sharpness	0.292
	Variance margin sharpness	0.227
	Variance radial gradient histogram	0.055

IMC Information measure of correlation