Table 3. Scope of palladium-catalyzed asymmetric coupling cyclization reaction of N-(buta-2,3-dienyl)amides and aryl iodides ^a .

^aUnless indicated otherwise, the experiments were performed with 1 (0.5 mmol), 2 (1.0 mmol), Pd₂(dba)₃·CHCl₃ (0.0125 mmol), L10 (0.0375 mmol), and Cs₂CO₃ (1.0 mmol) in benzene (6 mL) at rt (0.5 h) and 90 °C under Ar atmosphere.

^bThe reaction was conducted in 4 mL of benzene.

^cWith (S,S)-L10 purchased from Sigma-Aldrich, 90% ee of (R)-3ag was obtained.