Table 3.
Summary of hierarchical linear regression models of white matter connectivity between hippocampus and inferior parietal lobe microstructure (FA) predicting memory performances.
| Dependent variable | Predictors | β | t-value | F | ΔF | R2 | ΔR2 | |
|---|---|---|---|---|---|---|---|---|
| Children’s Memory Scale | ||||||||
| Immediate Recall | ||||||||
| Step 1 | 6.29*** | 0.46 | ||||||
| Age | 0.49 | 4.00** | ||||||
| Whole-brain FA | 0.10 | 0.78 | ||||||
| KBIT Verbal SS | 0.39 | 3.17* | ||||||
| [L] HC − V1 FA | −0.20 | −1.22 | ||||||
| [R] HC − V1 FA | 0.03 | 1.84 | ||||||
| Step 2 | 9.36** | 0.19 | ||||||
| Age | 0.52 | 4.83*** | ||||||
| Whole-brain FA | 0.16 | 1.41 | ||||||
| KBIT Verbal SS | 0.33 | 3.18* | ||||||
| [L] HC − V1 FA | 0.05 | 0.34 | ||||||
| [R] HC − V1 FA | 0.27 | 1.77 | ||||||
| [L] HC − IPL FA | −0.61 | −4.05** | ||||||
| [R] HC − IPL FA | 0.44 | 3.19* | ||||||
| Delayed Recall | ||||||||
| Step 1 | 4.44** | 0.40 | ||||||
| Age | 0.44 | 3.26* | ||||||
| Whole-brain FA | 0.08 | 0.59 | ||||||
| KBIT Verbal SS | 0.41 | 3.03* | ||||||
| [L] HC − V1 FA | −0.18 | −1.00 | ||||||
| [R] HC − V1 FA | 0.26 | 1.42 | ||||||
| Step 2 | 4.20* | 0.13 | ||||||
| Age | 0.47 | 3.63** | ||||||
| Whole-brain FA | 0.13 | 0.93 | ||||||
| KBIT Verbal SS | 0.37 | 2.94* | ||||||
| [L] HC − V1 FA | 0.03 | 0.16 | ||||||
| [R] HC − V1 FA | 0.22 | 1.26 | ||||||
| [L] HC − IPL FA | −0.50 | −2.62 | ||||||
| [R] HC − IPL FA | 0.36 | 12.16 | ||||||
| Delayed Recognition | ||||||||
| Step 1 | 1.82 | 0.20 | ||||||
| Age | 0.25 | 1.64 | ||||||
| Whole-brain FA | 0.14 | 0.87 | ||||||
| KBIT Verbal SS | 0.12 | 0.80 | ||||||
| [L] HC − V1 FA | −0.21 | −1.02 | ||||||
| [R] HC − V1 FA | 0.38 | 1.88 | ||||||
| Step 2 | 8.61** | 0.27 | ||||||
| Age | 0.35 | 2.63 | ||||||
| Whole-brain FA | 0.28 | 2.03 | ||||||
| KBIT Verbal SS | 0.10 | 0.76 | ||||||
| [L] HC − V1 FA | 0.03 | 0.13 | ||||||
| [R] HC − V1 FA | 0.50 | 2.63 | ||||||
| [L] HC − IPL FA | −0.77 | −4.12** | ||||||
| [R] HC − IPL FA | 0.24 | 1.39 | ||||||
| Episodic Memory | ||||||||
| Context Memory | ||||||||
| Step 1 | 1.45 | 0.16 | ||||||
| Age | 0.18 | 1.79 | ||||||
| Whole-brain FA | 0.18 | 1.23 | ||||||
| KBIT Nonverbal SS | −0.14 | −1.52 | ||||||
| [L] HC − V1 FA | −0.31 | −1.62 | ||||||
| [R] HC − V1 FA | 0.33 | 1.66 | ||||||
| Step 2 | 6.62 | 0.23 | ||||||
| Age | 0.06 | 0.40 | ||||||
| Whole-brain FA | 0.04 | 0.29 | ||||||
| KBIT Nonverbal SS | −0.27 | −1.90 | ||||||
| [L] HC − V1 FA | −0.14 | −0.70 | ||||||
| [R] HC − V1 FA | −0.03 | −0.16 | ||||||
| [L] HC − IPL FA | 0.03 | 0.16 | ||||||
| [R] HC − IPL FA | 0.60 | 3.19* | ||||||
FA: fractional anisotropy, β: standardized regression coefficient, HC – mPFC: white matter connecting hippocampus and medial prefrontal cortex, HC – V1: white matter connecting hippocampus and primary visual cortex.
ΔF: the change in F values between models 1 and 2. ΔR2: the change in R2 between models 1 and 2.
*** p < 0.001; ** p < 0.01; * p < 0.01 Bonferroni corrected (corrected α= 0.01 for Model 1 and corrected α= 0.007 for Model 2).