Table 4.

Summary of hierarchical linear regression models of white matter connectivity between hippocampus and medial prefrontal cortex microstructure (FA) predicting memory performances.

Dependent variable	Predictors	β	t-value	F	ΔF	R2	ΔR2
Children’s Memory Scale
Immediate Recall
Step 1				5.83***		0.43
	Age	0.48	3.88**
	Whole-brain FA	0.12	0.93
	KBIT Verbal SS	0.36	2.92*
	[L] HC − V1 FA	−0.13	−0.76
	[R] HC − V1 FA	0.31	1.78
Step 2					0.64**		0.02
	Age	0.49	3.94**
	Whole-brain FA	0.04	0.19
	KBIT Verbal SS	0.33	2.60
	[L] HC − V1 FA	−0.07	−0.41
	[R] HC − V1 FA	0.34	1.94
	[L] HC − mPFC FA	−0.18	−0.93
	[R] HC − mPFC FA	0.23	1.03
Delayed Recall
Step 1				4.00**		0.36
	Age	0.42	3.13*
	Whole-brain FA	0.10	0.72
	KBIT Verbal SS	0.38	2.78
	[L] HC − V1 FA	−0.10	−0.55
	[R] HC − V1 FA	0.26	1.37
Step 2					0.27		0.01
	Age	0.43	3.10*
	Whole-brain FA	−0.03	−0.13
	KBIT Verbal SS	0.36	2.51
	[L] HC − V1 FA	−0.08	−0.37
	[R] HC − V1 FA	0.25	1.30
	[L] HC − mPFC FA	0.02	0.09
	[R] HC − mPFC FA	0.15	0.57
Delayed Recognition
Step 1				1.95		0.20
	Age	0.26	1.77
	Whole-brain FA	0.14	0.89
	KBIT Verbal SS	0.12	0.81
	[L] HC − V1 FA	−0.23	−1.08
	[R] HC − V1 FA	0.39	1.92
Step 2					1.00		0.04
	Age	0.28	1.89
	Whole-brain FA	0.08	0.32
	KBIT Verbal SS	0.09	0.58
	[L] HC − V1 FA	−0.14	−0.65
	[R] HC − V1 FA	0.45	2.14
	[L] HC − mPFC FA	−0.31	−1.33
	[R] HC − mPFC FA	0.29	1.09
Episodic Memory
Context Memory
Step 1				1.45		0.15
	Age	0.22	1.48
	Whole-brain FA	0.17	1.12
	KBIT Nonverbal SS	−0.12	−0.77
	[L] HC − V1 FA	−0.25	−1.21
	[R] HC − V1 FA	0.30	1.46
Step 2					0.52		0.02
	Age	0.24	1.55
	Whole-brain FA	0.10	0.44
	KBIT Nonverbal SS	−0.14	−0.88
	[L] HC − V1 FA	−0.18	−0.82
	[R] HC − V1 FA	0.31	1.51
	[L] HC − mPFC FA	−0.19	−0.84
	[R] HC − mPFC FA	0.23	0.90

FA: fractional anisotropy, β: standardized regression coefficient, HC – mPFC: white matter connecting hippocampus and medial prefrontal cortex, HC – V1: white matter connecting hippocampus and primary visual cortex.

ΔF: the change in F values between models 1 and 2. ΔR²: the change in R² between models 1 and 2.

*** p < 0.001; ** p < 0.01; * p < 0.01 Bonferroni corrected (corrected α = 0.01 for Step 1 and corrected α = 0.007 for Step 2).