IL-13, PGE2, and PGI2 enhanced the proliferation and cell activity of HSCs. HSCs were treated with the solvent of drugs (Control), 5 μM IL-13, 2 μM PGE2, and 2 μM PGI2. BrdU assay results showing the enhanced proliferation of HSCs in response to IL-13, PGE2, and PGI2 compared to the control (A). CCK8 assay results showing the increased optical density (OD) of cell activity in response to IL-13, PGE2, and PGI2 compared to the control (B). Data are shown as the means ±SD. All differences were considered significant when * P<0.05 (n=6) compared with the solvent of drugs (Control).